-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	636914
标题:	Synthesis of N-propargylphenelzine and analogues as neuroprotective agents
作者:	Ling, L.; Urichuk, L.J.; Sloley, B.D.; Coutts, R.T.; Baker, G.B.; Shan, J.J.; Pang, P.K.T.
来源:	Bioorg Med Chem Lett 2001,11(20),2715

合成路线图解说明: The condensation of 2-phenylethylhydrazine (I) with propargyl bromide (II) by means of K2CO3 in aqueous acetonitrile gives the target hydrazine.

合成路线图解说明: The condensation of fully Boc-protected 2-phenylethylhydrazine (I) with propargyl bromide (II) by means of NaH gives the protected disubstituted hydrazine (III), which is finally deprotected with 4N HCl in dioxane to afford the target hydrazine.