【药物名称】
化学结构式(Chemical Structure):
参考文献No.636922
标题:Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain
作者:Roush, W.R.; Cheng, J.B.; Knapp-Reed, B.; Alvarez-Hernandez, A.; McKerrow, J.H.; Hansell, E.; Engel, J.C.
来源:Bioorg Med Chem Lett 2001,11(20),2759
合成路线图解说明:

The Horner-Wadsworth-Emmons olefination of N-(tert-butoxycarbonyl)-L-homophenylalaninal (I) with phosphonate (II) by means of NaH in THF gives the vinylsulfonate (III), which is treated with tetrabutylammonium iodide and triphosgene to yield the sulfonyl chloride (IV). The reaction of (IV) with O-benzylhydroxylamine in dichloromethane affords the N-sulfonylhydroxylamine derivative (V), which is deprotected with TFA in dichloromethane, providing compound (VI) with a free amino group. Finally, this compound is condensed with N-(morpholin-4-ylcarbonyl)-L-phenylalanine (VII) by means of HOBt, EDC and NMM in DMF, giving rise to the target amide.

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