-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	640346
标题:	Synthesis and antiinflammatory, analgesic activity of 3,-3'-(1,2-ethanediyl)-bis[2-aryl-4-thiazolidinone] chiral compounds, Part 10
作者:	Vigorita, M.G.; Ottana, R.; Monforte, F.; Maccari, R.; Trovato, A.; Monforte, M.T.; Taviano, M.F.
来源:	Bioorg Med Chem Lett 2001,11(21),2791

合成路线图解说明: The cyclocondensation of N,N'-bis(3,4-dichlorobenzylidene)ethylenediamine (I) with 2-sulfanylacetic acid (II) in refluxing toluene gives a mixture of the meso (R,S)-isomer and the corresponding racemate (R,R)+(S,S), which is easily separated by HPLC on a Chiracel OD column to obtain the target meso (R,S)-isomer.

参考文献No.	642008
标题:	3,3'-Bi(1,3-thiazolidin-4-one) system. VIII. 3,3'-(1,2-ethanedyl) derivatives ans corresponding 1,1'-disulfones: Synthesis, stereochemistry and antiinflammatory activity
作者:	Vigorita, M.G.; Previtera, T.; Ottana, R.; Grillone, I.; Monforte, F.; Monforte, M.T.; Trovato, A.; Rossitto, A.
来源:	Farmaco 1997,52(1),43

合成路线图解说明: The cyclocondensation of N,N'-bis(3,4-dichlorobenzylidene)ethylenediamine (I) with 2-sulfanylacetic acid (II) in refluxing toluene gives a mixture of the meso (R,S)-isomer and the corresponding racemate (R,R)+(S,S), which is easily separated by HPLC on a Chiracel OD column to obtain the target meso (R,S)-isomer.