-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	639257
标题:	Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP)
作者:	Romanelli, M.N.; Manetti, D.; Scapecchi, S.; Borea, P.A.; Dei, S.; Bartolini, A.; Ghelardini, C.; Gualtieri, F.; Guandalini, L.; Varani, K.
来源:	J Med Chem 2001,44(23),3946

合成路线图解说明: Pyridazinylpiperazine (III) was prepared from 3,6-dichloropyridazine (I) and N-methylpiperazine (II) according to a literature method. Subsequent quaternization of piperazine (III) with methyl iodide gave the title ammonium salt.

参考文献No.	687594
标题:	6-Chloropyridazin-3-yl derivatives active as nicotinic agents: Synthesis, binding, and modeling studies
作者:	Toma, L.; Quadrelli, P.; Bunnelle, W.H.; Anderson, D.J.; Meyer, M.D.; Cignarella, G.; Gelain, A.; Barlocco, D.
来源:	J Med Chem 2002,45(18),4011

合成路线图解说明: The condensation of 3,6-dichloropyridazine (I) with piperazine (II) by means of TEA in refluxing toluene gives 3-chloro-6-(1-piperazinyl)pyridazine (III), which is methylated with HCHO/ HCOOH at 110 C, yielding 3-chloro-6-(4-methylpiperazin-1-yl)pyridazine (IV). Finally, this compound is quaternized with methyl iodide in ethyl ether to provide the target dimethylpiperidinium salt.