KMUP-1-药物合成数据库

【药物名称】KMUP-1

化学结构式(Chemical Structure):

参考文献No.	2905
标题:	Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivs. as active ingredient
作者:	Kaneko, T.; Sugimoto, H.; Ozaki, S.; Takizawa, K. (Eisai Co., Ltd.)
来源:	DE 3307395; EP 0087810; US 4543254

合成路线图解说明: The title compound was prepared by alkylation of N-(2-chlorophenyl)piperazine (II) with 7-(2-bromoethyl)theophylline (I) in refluxing benzene.

参考文献No.	53467
标题:	Theophylline and theobromine derivs.
作者:	Nakamura, T.; Sugimoto, H.; Daiku, Y.; Igarashi, T.; Hamazo, S. (Eisai Co., Ltd.)
来源:	US 4426383; US 4564617

合成路线图解说明: The title compound was prepared by alkylation of N-(2-chlorophenyl)piperazine (II) with 7-(2-bromoethyl)theophylline (I) in refluxing benzene.