【药物名称】FR-252384
化学结构式(Chemical Structure):
参考文献No.668131
标题:Novel potent antagonists of human neuropeptide Y-Y5 receptor. Part 4: Tetrahydrodiazabenzazulene derivatives
作者:Satoh, Y.; Hatori, C.; Ito, H.
来源:Bioorg Med Chem Lett 2002,12(7),1009
合成路线图解说明:

Nitrosation of the benzocycloheptanone (I) with isoamyl nitrite furnishes the keto oxime (II). Subsequent ring closure of (II) with pyridine-3-carboxaldehyde (III) and ammonium acetate produces the N-hydroxy imidazole derivative (IV). Then, reduction of the N-hydroxy group of (IV) is performed by treatment PCl3 in DMF

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