【药物名称】SLV-319
化学结构式(Chemical Structure):
参考文献No.51337
标题:4,5-Dihydro-1H-pyrazole derivs. having CB 1-antagonistic activity
作者:Kruse, C.G.; Tulp, M.T.M.; Lange, J.H.M.; Tipker, J.; Van Vliet, B.J. (Solvay Pharmaceuticals BV)
来源:EP 1268435; US 2001053788; US 6476060; WO 0170700
合成路线图解说明:

Condensation of dihydropyrazole (I) with the sulfonyl carbamate (II) in the presence of pyridine gives rise to the 1-acyl dihydropyrazole (III). Subsequent chlorination of (III) using PCl5 in refluxing chlorobenzene affords the imidoyl chloride (IV). This is finally condensed with methylamine in CH2Cl2 to furnish the title compound.

参考文献No.58624
标题:4,5-Dihydro-1H-pyrazole derivs. having CB1-antagonistic activity
作者:Kruse, C.G.; Lange, J.H.M.; Tipker, J.; Hoogendoorn, J. (Solvay Pharmaceuticals BV)
来源:WO 0276949
合成路线图解说明:

Condensation of dihydropyrazole (I) with the sulfonyl carbamate (II) in the presence of pyridine gives rise to the 1-acyl dihydropyrazole (III). Subsequent chlorination of (III) using PCl5 in refluxing chlorobenzene affords the imidoyl chloride (IV). This is finally condensed with methylamine in CH2Cl2 to furnish the title compound.

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