【药物名称】
化学结构式(Chemical Structure):
参考文献No.644112
标题:Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5'-sulfonamide moiety of a phenyl ring
作者:Kim, D.-K.; Lee, J.Y.; Lee, N.; Ryu, D.H.; Kim, J.S.; Lee, S.; Choi, J.Y.; Ryu, J.H.; Kim, N.H.; Im, G.J.; Choi, W.S.; Kim, T.K.
来源:Bioorg Med Chem 2001,9(11),3013
合成路线图解说明:

Chlorosulfonylation of the benzamidopyrazole (I) to give (II) was performed with neat chlorosulfonic acid at 0 C. Coupling of sulfonyl chloride (II) with the piperidinopropanoate (III) provided sulfonamide (IV). Finally, cyclization of (IV) with concomitant ester hydrolysis under basic conditions furnished the target pyrazolopyrimidine.

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