【药物名称】
化学结构式(Chemical Structure):
参考文献No.646955
标题:alpha-Adrenoceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole
作者:Gentili, F.; Bousquet, P.; Brasili, L.; Caretto, M.; Carrieri, A.; Dontenwill, M.; Giannella, M.; Marucci, G.; Perfumi, M.; Piergentili, A.; Quaglia, W.; Rascente, C.; Pigini, M.
来源:J Med Chem 2002,45(1),32
合成路线图解说明:

The title compound is prepared starting from the known (S) methyl 2-(biphenyl-2-yloxy)propionate (I). Treatment of ester (I) with ethylenediamine (II) in the presence of AlMe3 gives rise to the corresponding imidazoline (II) with some loss of optical purity. Enantiomeric enrichment of (II) is accomplished by fractional crystallization with (-)-di-O,O'-p-toluoyl-L-tartaric acid. The optically pure imidazoline is finally isolated as the corresponding oxalate salt.

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