-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	32261
标题:	Progesterone analogs to reverse multidrug resistance
作者:	Clarke, R.; Talebian, A.H.; Ghiorghis, A.; Leonessa, F.; Hammer, C. (Georgetown University)
来源:	WO 9700683

合成路线图解说明: Progesterone (I) was oxidized to the 6-dehydro derivative (II) using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Conjugate addition of 4-aminothiophenol (III) to dienone (II) furnished the aminophenyl sulfide (IV). The target urea was then obtained by coupling of the amino compound (IV) with (R)-alpha-methylbenzyl isocyanate (V).

参考文献No.	647829
标题:	C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump
作者:	Leonessa, F.; Kim, J.-H.; Ghiorghis, A.; Kulawiec, R.J.; Clarke, R.; Talebian, A.; Hammer, C.
来源:	J Med Chem 2002,45(2),390

合成路线图解说明: Progesterone (I) was oxidized to the 6-dehydro derivative (II) using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Conjugate addition of 4-aminothiophenol (III) to dienone (II) furnished the aminophenyl sulfide (IV). The target urea was then obtained by coupling of the amino compound (IV) with (R)-alpha-methylbenzyl isocyanate (V).