-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	49409
标题:	Gallotannins and ellagitannins as regulators of cytokine release
作者:	Feldman, K.S. (Penn State Research Foundation)
来源:	WO 0136436

合成路线图解说明: Selective hydrolysis of the 1-ester group of per-O-benzyl pentagalloylglucopyranose (I) by means of ammonia in MeOH-THF produced the pentagalloyl derivative (II). Coupling of (II) with pimeloyl chloride (III) yielded the bis-glucopyranosyl pimelate ester (IV).

合成路线图解说明: The O-benzyl protecting groups of (IV) were removed by catalytic hydrogenation over Pd/C to produce the title compound.

参考文献No.	650894
标题:	In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-alpha production by dimeric gallotannin analogues
作者:	Feldman, K.S.; Wilson, S.L.; Lawlor, M.D.; Lang, C.H.; Scheuchenzuber, W.J.
来源:	Bioorg Med Chem 2002,10(1),47

合成路线图解说明: Selective hydrolysis of the 1-ester group of per-O-benzyl pentagalloylglucopyranose (I) by means of ammonia in MeOH-THF produced the pentagalloyl derivative (II). Coupling of (II) with pimeloyl chloride (III) yielded the bis-glucopyranosyl pimelate ester (IV).

合成路线图解说明: The O-benzyl protecting groups of (IV) were removed by catalytic hydrogenation over Pd/C to produce the title compound.