-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	654104
标题:	SAR studies of 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one as inhibitors of 4-hydroxyphenylpyruvate dioxygenase
作者:	Lin, Y.-L.; Wu, C.-S.; Lin, S.-W.; Huang, J.-L.; Sun, Y.-S.; Yang, D.-Y.
来源:	Bioorg Med Chem 2002,10(3),685

合成路线图解说明: The chlorination of cyclohexane-1,3-dione (I) with chloramine T in acetonitrile gives 2-chlorocyclohexane-1,3-dione (II), which is finally condensed with cyclopropanecarbonyl chloride (III) by means of potassium tert-butoxide in THF to yield the target cyclohexenyl ester.