-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	654257
标题:	Synthesis, pharmacokinetics, efficacy, and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate
作者:	Macky, T.A.; Oelkers, C.; Rix, U.; Heredia, M.L.; K黱zel, E.; Winberly, M.; Rohr, J.; Crosson, C.E.; Rohrer, B.
来源:	J Med Chem 2002,45(5),1122

合成路线图解说明: The reaction of triamcinolone (I) with acetone and HCl gives the corresponding acetonide (II), which is condensed with glutaric anhydride (III) in pyridine to yield the glutaric monoester (IV). Finally, this compound is condensed with mitomycin C (V) by means of CDI in THF to afford the target conjugate.