G25-药物合成数据库

【药物名称】G25

化学结构式(Chemical Structure):

参考文献No.	53968
标题:	Antimalarial and anti-babesiosis agents and pharmaceutical compsns. containing same
作者:	Vial, H.; Calas, M.; Ancelin, M.-L.; Giral, L.
来源:	FR 2751967; WO 9804252

合成路线图解说明: The title bis-ammonium salt is obtained by quaternization of N-methyl pyrrolidine (II) with 1,16-dibromohexadecane (I) in refluxing EtOH.

参考文献No.	565872
标题:	Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: Comparison between mono- and bisquaternary ammonium salts
作者:	Calas, M.; Ancelin, M.L.; Cordina, G.; Portefaix, P.; Piquet, G.; Vidal-Sailhan, V.; Vial, H.
来源:	J Med Chem 2000,43(3),505

合成路线图解说明: The title bis-ammonium salt was prepared by quaternization of triethylamine (II) with 1,21-dibromoeicosane (I) in refluxing EtOH.

合成路线图解说明: The title bis-ammonium salt is obtained by quaternization of N-methyl pyrrolidine (II) with 1,16-dibromohexadecane (I) in refluxing EtOH.