-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	54909
标题:	Use of chemical chelators as reversal agents for drug-induced neuromuscular block
作者:	Muir, A.W.; Rees, D.; Bom, A.H.A. (Akzo Nobel N.V.)
来源:	WO 0112202

合成路线图解说明: Fischer esterification of 5,5'-methylene-bis-salicylic acid (I) with methanolic HCl gives the dimethyl ester (II). Alkylation of the phenolic hydroxyls of (II) with 2,6-di(bromomethyl)naphthalene (III) affords the bis-naphthylmethyl ether (IV). Then, macrocyclization of dibromide (IV) with a further molecule of 5,5'-methylene-bis-salicylic acid dimethyl ester (II) produces the tetraoxacyclophane derivative (V). Finally, basic hydrolysis of the methyl ester groups of (V) produces the title tetracarboxylic acid.

参考文献No.	660106
标题:	Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation
作者:	Cameron, K.S.; Fielding, L.; Mason, R.; Muir, A.W.; Rees, D.C.; Thorn, S.; Zhang, M.Q.
来源:	Bioorg Med Chem Lett 2002,12(5),753

合成路线图解说明: Fischer esterification of 5,5'-methylene-bis-salicylic acid (I) with methanolic HCl gives the dimethyl ester (II). Alkylation of the phenolic hydroxyls of (II) with 2,6-di(bromomethyl)naphthalene (III) affords the bis-naphthylmethyl ether (IV). Then, macrocyclization of dibromide (IV) with a further molecule of 5,5'-methylene-bis-salicylic acid dimethyl ester (II) produces the tetraoxacyclophane derivative (V). Finally, basic hydrolysis of the methyl ester groups of (V) produces the title tetracarboxylic acid.