AWD-47-222-药物合成数据库

【药物名称】AWD-47-222

化学结构式(Chemical Structure):

参考文献No.	54312
标题:	6,7-Dihydro-pyrrolo[3,4-b]pyridin-5-ones with an anticonvulsive action and methods for producing the same
作者:	Rostock, A.; Lankau, H.-J.; Unverferth, K.; Tober, C.; Rundfeldt, C.; Arnold, T.; Dost, R.; Gasparic, A. (AWD.pharma GmbH & Co. KG)
来源:	DE 10042093; WO 0218381

合成路线图解说明: Condensation of lactone (I) with 2,6-difluorobenzylamine (II) provides the 2-(hydroxymethyl)nicotinamide (III). This is then chlorinated in refluxing SOCl2 to furnish the 2-(chloromethyl) pyridine (IV). Intramolecular cyclization of (IV) in the presence of K2CO3 in hot DMF gives rise to the title compound. (1,2)

参考文献No.	674859
标题:	Synthesis and anticonvulsant activity of AWD 47-222
作者:	Lankau, H.-J.; Arnold, T.; Dost, R.; Rundfeldt, C.; Unverferth, K.
来源:	28th Natl Med Chem Symp (June 8 2002, San Diego) 2002,Abst 21

合成路线图解说明: Condensation of lactone (I) with 2,6-difluorobenzylamine (II) provides the 2-(hydroxymethyl)nicotinamide (III). This is then chlorinated in refluxing SOCl2 to furnish the 2-(chloromethyl) pyridine (IV). Intramolecular cyclization of (IV) in the presence of K2CO3 in hot DMF gives rise to the title compound. (1,2)