NSC-724771, JS-K-药物合成数据库

【药物名称】NSC-724771, JS-K

化学结构式(Chemical Structure):

参考文献No.	54904
标题:	O2-Arylated or O2-glycosylated 1-substd. diazen-1-ium-1,2-diolates and O2-substd. 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
作者:	Keefer, L.K.; Saavedra, J.E.; Srinivasan, A.; Rice, W.G.; Bogdan, C.; Ji, X. (US Department of Health & Human Services)
来源:	JP 2002506421; WO 9813358

合成路线图解说明: Reaction of piperazine-1-carboxylic acid ethyl ester (I) with nitric oxide in the presence of NaOMe in a pressure bottle gives rise to the sodium piperazinyldiazenium diolate (II). This is finally condensed with 2,4-dinitrofluorobenzene (III) to produce the title compound.

参考文献No.	665061
标题:	The secondary amine/nitric oxide complex ion R2N[N(O)NO](-) as nucleophile and leaving group in S(N)Ar reactions
作者:	Saavedra, J.E.; Srinivasan, A.; Bonifant, C.L.; Chu, J.-Y.; Shanklin, A.P.; Flippen-Anderson, J.L.; Rice, W.G.; Turpin, J.A.; Davies, K.M.; Keefer, L.K.
来源:	J Org Chem 2001,66(9),3090

合成路线图解说明: Reaction of piperazine-1-carboxylic acid ethyl ester (I) with nitric oxide in the presence of NaOMe in a pressure bottle gives rise to the sodium piperazinyldiazenium diolate (II). This is finally condensed with 2,4-dinitrofluorobenzene (III) to produce the title compound.