-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	44709
标题:	Arylaminoalkylamides
作者:	Missbach, M.; Altmann, E.; Lattmann, R.; Renaud, J. (Novartis AG)
来源:	WO 0048993

合成路线图解说明: Condensation of p-anisidine (I) with 2-oxazolidinone (II) in hot 2-(2-methoxyethoxy)ethanol affords the N-aryl ethanediamine (III). This is then coupled with the succinimidyl ester of N-Z-L-leucine (IV) to furnish amide (V). The N-carbobenzoxy group of (V) is further removed by catalytic hydrogenation, providing amine (VI), which is finally acylated by 4-(benzyloxy)benzoic acid (VII) by means of HATU to yield the title compound.

参考文献No.	672298
标题:	Arylaminoethyl amides as novel non-covalent cathepsin K inhibitors
作者:	Altmann, E.; Renaud, J.; Green, J.; Farley, D.; Cutting, B.; Jahnke, W.
来源:	J Med Chem 2002,45(12),2352

合成路线图解说明: Condensation of p-anisidine (I) with 2-oxazolidinone (II) in hot 2-(2-methoxyethoxy)ethanol affords the N-aryl ethanediamine (III). This is then coupled with the succinimidyl ester of N-Z-L-leucine (IV) to furnish amide (V). The N-carbobenzoxy group of (V) is further removed by catalytic hydrogenation, providing amine (VI), which is finally acylated by 4-(benzyloxy)benzoic acid (VII) by means of HATU to yield the title compound.