-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	669077
标题:	Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging
作者:	Fu, X.; Tan, P.-Z.; Kula, N.S.; Baldessarini, R.; Tamagnan, G.; Innis, R.B.; Baldwin, R.M.
来源:	J Med Chem 2002,45(11),2319

合成路线图解说明: Alkylation of 4-(p-fluorobenzoyl)piperidine (I) with p-fluorophenethyl bromide (II) in hot methyl isobutyl ketone provides the disubstituted piperidine (III). Subsequent keto group reduction in (III) by means of NaBH4 furnishes the title carbinol compound.