【药物名称】CP-533536
化学结构式(Chemical Structure):
参考文献No.39053
标题:Prostaglandin agonists and their use to treat bone disorders
作者:Rosati, R.L.; Lefker, B.A.; Cameron, K.O. (Pfizer Inc.)
来源:EP 1021410; JP 2001519414; US 6498172; WO 9919300
合成路线图解说明:

Alkylation of 3-hydroxybenzaldehyde (I) with t-butyl bromoacetate (II) affords t butyl (3-formylphenoxy)acetate (III). Aldehyde (III) is then converted to oxime (IV) upon treatment with hydroxylamine in MeOH. Reduction of oxime (IV) to the benzylic amine (V) is carried out by catalytic hydrogenation in the presence of Raney nickel. Subsequent reductive alkylation of amine (V) with 4-t-butylbenzaldehyde (VI) furnishes the secondary amine (VII). This is then acylated by pyridine-3-sulfonyl chloride (VIII) producing sulfonamide (IX). The t-butyl ester group of (IX) is finally cleaved with trifluoroacetic acid to give the corresponding carboxylic acid.

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