【药物名称】
化学结构式(Chemical Structure):
参考文献No.674912
标题:Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum
作者:Guan, J.; et al.
来源:J Med Chem 2002,45(13),2741
合成路线图解说明:

4-Chloro-1-butanol (I) is protected as the tetrahydropyranyl ether (III) by treatment with dihydropyran (II) in the presence of pyridinium p-toluenesulfonate (PPTS). Alkylation of the sodium derivative of phenothiazine (IV) with chloride (III) yields adduct (V), which is subsequently deprotected to alcohol (VI) with PPTS in MeOH-THF. The free alcohol (VI) is then chlorinated to (VII) by using SOCl2 in benzene. Finally, condensation of chloride (VII) with pyrrolidine (VIII) in THF at 100 C in a sealed tube provides the title compound.

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