-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	67581
标题:	Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use
作者:	Du, X.; Cohen, F.E.; McKerrow, J.H.; Guo, C. (University of California, Oakland)
来源:	US 2004014801

合成路线图解说明: The title thio semicarbazone is prepared by condensation of 3-bromopropiophenone (I) with thio semicarbazide (II) in MeOH in the presence of a catalytic amount of HOAc. (1,2)

参考文献No.	674917
标题:	Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain
作者:	Du, X.; et al.
来源:	J Med Chem 2002,45(13),2695

合成路线图解说明: The title thio semicarbazone is prepared by condensation of 3-bromopropiophenone (I) with thio semicarbazide (II) in MeOH in the presence of a catalytic amount of HOAc. (1,2)