A-331440, ABBOTT-331440-药物合成数据库

【药物名称】A-331440, ABBOTT-331440

化学结构式(Chemical Structure):

参考文献No.	53474
标题:	1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
作者:	Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.)
来源:	WO 0206223

合成路线图解说明: The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.

参考文献No.	55964
标题:	1,3-Disubstd. and 1,3,3-trisubstd. pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
作者:	Faghih, R.; Bennani, Y.L.; Dwight, W.J.; Vasudevan, A.; Conner, S.E. (Abbott Laboratories Inc.)
来源:	US 2002035103; US 6515013

合成路线图解说明: The title compound is prepared by a displacement reaction between 4'-(3-chloropropoxy)biphenyl-4-carbonitrile (I) and 3(R)-(dimethylamino)pyrrolidine (II) in the presence of K2CO3 and KI in refluxing 2-butanone.