-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	681693
标题:	Synthesis and cytotoxic activity of N-(2-diethylamino)ethylcarboxamide and other derivatives of 10H-quindoline
作者:	Chen, J.; Deady, L.W.; Kaye, A.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.
来源:	Bioorg Med Chem 2002,10(7),2381

合成路线图解说明: Methylation of 6-methyl-10H-quindoline-4-carboxylic acid (I) with iodomethane in the presence of KOH in DMSO takes place at both the indole N and the carboxylate group, producing (II). Subsequent aminolysis of ester (II) with N,N-dimethylethanediamine (III) in refluxing dioxan furnishes the target amide.