【药物名称】ST-1863
化学结构式(Chemical Structure):
参考文献No.688321
标题:New phenylalkylcarboxylate derivatives as hypoglycemic and hypolipidemic agents
作者:Catini, R.; Brunetti, T.; Arduini, A.; et al.
来源:Drugs Fut 2002,27(Suppl. A),
合成路线图解说明:

Knoevenagel condensation of 4-hydroxybenzaldehyde (I) with dimethyl malonate in the presence of pyridinium acetate affords the benzylidene malonate (II), which is further hydrogenated over Pd/C to furnish dimethyl (4-hydroxybenzyl)malonate (III). Then, Mitsunobu coupling between phenol (III) and 4-chlorophenethyl alcohol (IV) gives rise to the title compound.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us