【药物名称】MCB-116
化学结构式(Chemical Structure):
参考文献No.56637
标题:Antimicrobial quinolone derivs. and use of the same to treat bacterial infections
作者:Barbachyn, M.R.; Patel, D.V.; Gage, J.R.; Gordeev, M.F. (Pharmacia Corp.)
来源:WO 0259116
合成路线图解说明:

The title adduct is prepared by condensation between the piperazinyl oxazolidinone derivative (I) and chloroquinoline (II) in hot N-methylpyrrolidinone.

参考文献No.693333
标题:Synthesis and antibacterial action of novel quinolone-linked oxazolidinones
作者:Locher, H.H.; Specklin, J.; Borer, Y.; Brohammer, S.; Schroeder, S.; Sigwalt, C.; Hubschwerlen, C.
来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002,Abst F-1317
合成路线图解说明:

The title adduct is prepared by condensation between the piperazinyl oxazolidinone derivative (I) and chloroquinoline (II) in hot N-methylpyrrolidinone.

参考文献No.778003
标题:Novel oxazolidinone-quinolone hybrid antimicrobials
作者:Gordeev, M.F.; Hackbarth, C.; Barbachyn, M.R.; Bannit, L.S.; Gage, J.R.; Luehr, G.W.; Gomez, M.; Trias, J.; Morin, S.E.; Zurenko, G.E.; Parker, C.N.; Evans, J.M.; White, R.J.; Patel, D.V.
来源:Bioorg Med Chem Lett 2003,13(23),4213
合成路线图解说明:

The title adduct is prepared by condensation between the piperazinyl oxazolidinone derivative (I) and chloroquinoline (II) in hot N-methylpyrrolidinone.

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