【药物名称】Epidoxoform
化学结构式(Chemical Structure):
参考文献No.56913
标题:Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity: Cpds., compsns. and methods
作者:Taatjes, D.J.; Fenick, D.J.; Koch, T.H. (University Technology Corp.)
来源:JP 2002514213; US 6677309; WO 9846598
合成路线图解说明:

The title compound is obtained by dimerization of epidoxorubicin hydrochloride (I) in the presence of an excess of formaldehyde in a triethylammonium acetate buffer at pH 6. (1-3)

参考文献No.691332
标题:Evaluation of the epidoxorubicin-formaldehyde conjugate, epidoxoform, in a mouse mammary carcinoma model
作者:Dernell, W.S.; Powers, B.E.; Taatjes, D.J.; Cogan, P.; Gaudiano, G.; Koch, T.H.
来源:Cancer Invest 2002,20(5-6),713
合成路线图解说明:

The title compound is obtained by dimerization of epidoxorubicin hydrochloride (I) in the presence of an excess of formaldehyde in a triethylammonium acetate buffer at pH 6. (1-3)

参考文献No.693931
标题:Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells
作者:Taatjes, D.J.; Fenick, D.J.; Koch, T.H.
来源:J Med Chem 1998,41(8),1306
合成路线图解说明:

The title compound is obtained by dimerization of epidoxorubicin hydrochloride (I) in the presence of an excess of formaldehyde in a triethylammonium acetate buffer at pH 6. (1-3)

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us