【药物名称】AC98-6446
化学结构式(Chemical Structure):
参考文献No.694052
标题:Synthesis of AC98-6446, a semisynthetic mannopeptimycin derivative
作者:Dushin, R.G.; Wang, T.; Fortier, G.; Iera, S.; Papamichelakis, M.; Richard, L.; Sellstedt, J.; Shah, S.
来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002,Abst F-352
合成路线图解说明:

The title compound is obtained by ketalization of glycopeptide AC98-0053 (I) with adamantanone dimethyl ketal (II) under acidic conditions in DMSO. In turn, glycopeptide (I) can be obtained by two different ways: 1) Through biosynthetic precursor feeding of cyclohexylalanine to fermentation broths of certain strains of S. hygroscopicus (this method permits only small quantities of (I)). 2) By selective hydrogenation of glycopeptide AC98-7809 (III) 杘btained from high-yielding mutants of S. hygroscopicus- employing Rh/C in aqueous AcOH. (By following this general process it is possible to scale-up the whole process to prepare several hundred grams of the title product).

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