EP-1579-药物合成数据库

【药物名称】EP-1579

化学结构式(Chemical Structure):

参考文献No.	62833
标题:	11-O-Substd. macrolides and their descladinose derivs.
作者:	Or, Y.S.; Phan, L.T.; Niu, D. (Enanta Pharmaceuticals, Inc.)
来源:	US 2003114396; US 6673774; WO 0347600

合成路线图解说明: Alkylation of clarithromycin diacetate (I) with allyl t-butyl carbonate (II) in the presence of palladium catalyst affords the 11-O-allyl ether (III). Subsequent metathesis reaction between ally ether (III) and 1-butenyl-4-phenylimidazole (IV) employing Grubb's catalyst provides adduct (V). Finally, methanolysis of the 2'-acetate ester of (V) gives rise to the target compound.

参考文献No.	694153
标题:	Syntheses and antibacterial activities of novel 11-O-substituted macrolide and ketolide derivatives
作者:	Niu, D.; Phan, L.T.; Haley, T.; Polemeropoulos, A.; Or, Y.
来源:	42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002,Abst F-1666

合成路线图解说明: Alkylation of clarithromycin diacetate (I) with allyl t-butyl carbonate (II) in the presence of palladium catalyst affords the 11-O-allyl ether (III). Subsequent metathesis reaction between ally ether (III) and 1-butenyl-4-phenylimidazole (IV) employing Grubb's catalyst provides adduct (V). Finally, methanolysis of the 2'-acetate ester of (V) gives rise to the target compound.