【药物名称】OPT-11
化学结构式(Chemical Structure):
参考文献No.694402
标题:The synthesis and biological activity of multivalent aminoglycoside analogues of OPT-11
作者:Liang, C.; Duffield, J.J.; Marby, K.A.; Rabuka, D.; Romero, A.; Sgarbi, P.W.M.; Shue, Y.-K.; Sucheck, J.; Yao, S.; Zhang, Z.; Cheng, M.; Chan, F.K.; Hu, C.; Ng, S.P.; Hwang, S.-B.
来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002,Abst F-1687
合成路线图解说明:

The protected azidoglycoside derivative (I) is condensed with (R)-glycidol tosylate (II) to produce the glycidyl ether (III). Epoxide opening in (III) with N,N'-dimethyl-1,4-butanediamine (IV) furnishes the diamine-linked bis azidoglycoside (V). The title compound is then obtained by simultaneous reduction of the azido groups and O benzyl groups cleavage in (V) upon catalytic hydrogenation over Pearlman's catalyst.

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