Enzymatic hydrolysis of the N-decanoyl moiety of the daptomycin derivative (I) employing deacylase from Actinoplanes utahensis gives the aminoacid core (II). Reacylation of (II) with 4'-chloro-4-biphenylylacetic acid (III) via activation with DCC and pentafluorophenol affords amide (IV).

The N-Boc group of (IV) is finally removed by treatment with trifluoroacetic acid to furnish the title compound.