TX-1925-药物合成数据库

【药物名称】TX-1925

化学结构式(Chemical Structure):

参考文献No.	696687
标题:	TX-1123: An antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity
作者:	Hori, H.; Nagasawa, H.; Ishibashi, M.; Uto, Y.; Hirata, A.; Saijo, K.; Ohkura, K.; Kirk, K.L.; Uehara, Y.
来源:	Bioorg Med Chem 2002,10(10),3257

合成路线图解说明: The title compound is prepared by condensation of 3,5-di-t-butyl-4-methoxybenzaldehyde (I) with cyclopentene-1,3-dione (II) in the presence of p-toluenesulfonic acid in refluxing chloroform.