合成路线图解说明: Condensation of anthranilic acid (I) with 4-chloro-3-nitrobenzenesulfonyl chloride (II) in the presence of Na2CO3 affords sulfonamide (III). Electrophilic chlorination of (III) employing sulfuryl chloride in hot AcOH leads to (IV). After activation of acid (IV) as the corresponding acid chloride (V), coupling with 4-chloroaniline (VI) furnishes the target anthranilamide. |