Pittsburgh Compound B, PIB, 6-OH-BTA-1-药物合成数据库

【药物名称】Pittsburgh Compound B, PIB, 6-OH-BTA-1

化学结构式(Chemical Structure):

参考文献No.	736144
标题:	Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
作者:	Mathis, C.A.; Wang, Y.; Holt, D.P.; Huang, G.-F.; Debnath, M.L.; Klunk, W.E.
来源:	J Med Chem 2003,46(13),2740

合成路线图解说明: Condensation of 2-amino-5-methoxythiophenol (I) with 4-(methylamino)benzoic acid (II) in hot polyphosphoric acid produces the benzothiazole derivative (III), which is finally submitted to methyl ether cleavage by means of BBr3 to give the target hydroxy compound.