A-317344((R)-isomer), A-317491-药物合成数据库

【药物名称】A-317344((R)-isomer), A-317491

化学结构式(Chemical Structure):

参考文献No.	58729
标题:	Trisubstd.-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors
作者:	Lee, C.-H.; Stewart, A.O.; Perner, R.J.; Zheng, G.Z.; Larson, D.P.; Koenig, J.R.; Gomtsyan, A.R.; Didomenico, S.; Bayburt, E.K. (Abbott Laboratories Inc.)
来源:	US 2002173665; WO 0294767

合成路线图解说明: The reductive alkylation of (S)-1,2,3,4-tetrahydro-1-naphthalenylamine (I) with 3-phenoxybenzaldehyde (II) in the presence of NaBH4 affords the secondary amine (III), which is then acylated with 1,2,4,5-benzenetetracarboxylic dianhydride (IV), followed by aqueous hydrolysis to furnish the title compound.