IMPY-药物合成数据库

【药物名称】IMPY

化学结构式(Chemical Structure):

参考文献No.	64593
标题:	Amyloid plaque aggregation inhibitors and diagnostic imaging agents
作者:	Kung, H.; Kung, M.-P.; Zhuang, Z.-P. (University of Pennsylvania)
来源:	CA 2444214; EP 1381604; US 2003059369; WO 0285903

合成路线图解说明: Condensation between 2-bromo-4'-(dimethylamino)acetophenone (I) and 2-amino-5-bromopyridine (II) gives rise to the imidazopyridine (III). Subsequent palladium-catalyzed stannylation of (III) affords the tributyltin derivative (IV). The target radio-iodinated compound is then obtained by iododstannylation of (IV) with [125I] iodide in the presence of H2O2 (1,2)

参考文献No.	712270
标题:	Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain
作者:	Zhuang, Z.-P.; Kung, M.-P.; Wilson, A.; Lee, C.-W.; Pl鰏sl, K.; Hou, C.; Holtzman, D.M.; Kung, H.F.
来源:	J Med Chem 2003,46(2),237

合成路线图解说明: Condensation between 2-bromo-4'-(dimethylamino)acetophenone (I) and 2-amino-5-bromopyridine (II) gives rise to the imidazopyridine (III). Subsequent palladium-catalyzed stannylation of (III) affords the tributyltin derivative (IV). The target radio-iodinated compound is then obtained by iododstannylation of (IV) with [125I] iodide in the presence of H2O2 (1,2)