-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	714381
标题:	Synthesis and in vitro and in vivo antimalarial activity of N(1)-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives
作者:	Ryckebusch, A.; Deprez-Poulain, R.; Maes, L.; Debreu-Fontaine, M.A.; Mouray, E.; Grellier, P.; Sergheraert, C.
来源:	J Med Chem 2003,46(4),542

合成路线图解说明: Condensation of N,N'-bis-(3-aminopropyl)piperazine (I) with 4,7-dichloroquinoline (II) in refluxing pentanol affords adduct (III). Then reductive alkylation of the primary amino group of (III) with cyclopropanecarboxaldehyde (IV) in the presence of NaBH(OAc)3 provides the title compound.