-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	719541
标题:	Trypanocidal activity of conformationally restricted pentamidine congeners
作者:	Donkor, I.O.; Huang, T.L.; Tao, B.; Rattendi, D.; Lane, S.; Vargas, M.; Goldberg, B.; Bacchi, C.
来源:	J Med Chem 2003,46(6),1041

合成路线图解说明: Condensation of 4-fluorobenzonitrile (I) with piperazine (II) in hot DMSO gives rise to the dinitrile adduct (III). This is then converted into imidate (IV) with HCl/EtOH. Treatment of imidate (IV) with ethanolic ammonia furnishes the corresponding bis-amidine derivative, which is finally isolated as the dihydrochloride salt. (1,2)

参考文献No.	720747
标题:	Synthesis and anti-Pneumocystis carinii activity of conformationally restricted analogues of pentamidine
作者:	Tao, B.; Huang, T.L.; Zhang, Q.; Jackson, L.; Queener, S.F.; Donkor, I.O.
来源:	Eur J Med Chem 1999,34(6),531

合成路线图解说明: Condensation of 4-fluorobenzonitrile (I) with piperazine (II) in hot DMSO gives rise to the dinitrile adduct (III). This is then converted into imidate (IV) with HCl/EtOH. Treatment of imidate (IV) with ethanolic ammonia furnishes the corresponding bis-amidine derivative, which is finally isolated as the dihydrochloride salt. (1,2)