2,6-Dibromopyridine (I) is converted to its N-oxide (II), which undergoes electrophilic nitration at position 4 with HNO3/H2SO4 to yield compound (III). Subsequent selective reduction of the N-oxide group of (III) to afford 2,6-dibromo-4-nitropyridine (IV) is accomplished by treatment with PBr3 in acetonitrile (1). Nucleophilic displacement of the 4-nitro group of (IV) with potassium p-nitrothiophenoxide (V) leads to sulfide (VI). This is oxidized to sulfone (VII) with m-chloroperbenzoic acid, and followed by reduction of the nitro group of (VII) to amine (VIII) with Fe and NH4Cl. Finally, displacement of one bromo substituent of (VIII) with pyrrolidine (IX) in dioxane gives rise to the title pyrrolidinylpyridine derivative (1,2).

2,6-Dibromopyridine (I) is converted to its N-oxide (II), which undergoes electrophilic nitration at position 4 with HNO3/H2SO4 to yield compound (III). Subsequent selective reduction of the N-oxide group of (III) to afford 2,6-dibromo-4-nitropyridine (IV) is accomplished by treatment with PBr3 in acetonitrile (1). Nucleophilic displacement of the 4-nitro group of (IV) with potassium p-nitrothiophenoxide (V) leads to sulfide (VI). This is oxidized to sulfone (VII) with m-chloroperbenzoic acid, and followed by reduction of the nitro group of (VII) to amine (VIII) with Fe and NH4Cl. Finally, displacement of one bromo substituent of (VIII) with pyrrolidine (IX) in dioxane gives rise to the title pyrrolidinylpyridine derivative (1,2).