-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	45163
标题:	Substd. dimeric cpds., process for their preparation and pharmaceutical compsns. thereof
作者:	Guillaumet, G.; Renard, P.; Lesieur, D.; Yous, S.; Descamps-Francois, C.; Lefoulon, F.; Viaud, M.-C.; Delagrange, P.; Bennejean, C. (ADIR et Cie.)
来源:	EP 1038863; FR 2791344; JP 2000319242; US 2002035114; US 6319930; US 6635650

合成路线图解说明: Demethylation of N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide (I) with boron tribromide-dimethyl sulfide complex affords phenol (II). This is then alkylated with 3-bromopropanol (III) in the presence of K2CO3 to provide the hydroxypropyl derivative (IV). After conversion of alcohol (IV) into the corresponding mesylate (V), condensation with a further equivalent of phenol (II) in hot DMF furnishes the target dimeric compound

参考文献No.	721073
标题:	Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands
作者:	Descamps-Fran鏾is, C.; Yous, S.; Chavatte, P.; Audinot, V.; Bonnaud, A.; Boutin, J.A.; Delagrange, P.; Bennejean, C.; Renard, P.; Lesieur, D.
来源:	J Med Chem 2003,46(7),1127

合成路线图解说明: In an alternative method, the title dimer compound is obtained by condensation of two equivalents of N-[2-(7-hydroxynaphth-1-yl)ethyl]acetamide (I) with 1,3-dibromopropane (II) in the presence of K2CO3 in acetonitrile