SB-691673-药物合成数据库

【药物名称】SB-691673

化学结构式(Chemical Structure):

参考文献No.	718495
标题:	Identification of a novel series of selective 5-HT7 receptor antagonists
作者:	Forbes, I.T.; Cooper, D.G.; Dodds, E.K.; Douglas, S.E.; Gribble, A.D.; Ife, R.J.; Lightfoot, A.P.; Meeson, M.; Campbell, L.P.; Coleman, T.; Riley, G.J.; Thomas, D.R.
来源:	Bioorg Med Chem Lett 2003,13(6),1055

合成路线图解说明: Benzazepinone (I) is alkylated by allyl bromide (II) in the presence of NaH to furnish (III). Ozonolysis of the N-allyl group of (III) in cold CH2Cl2 then produces aldehyde (IV). This is then reductively aminated with 5-fluoro-1-(piperidin-4-yl)-2,3-dihydro-1H-benzimidazol-2-one (V) employing NaBH(OAc)3 in 1,2-dichloroethane to yield the title compound.