-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	62098
标题:	Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
作者:	Schwartz, J.-C.; Lecomte, J.-M.; Arrang, J.-M.; Garbarg, M.; Ganellin, C.R.; Stark, H.; Ligneau, X.; Schunack, W.G.; Leurquin, F.; Sigurd, E. (Societe Civile Bioprojet)
来源:	EP 1100503; EP 1428820; WO 0006254

合成路线图解说明: Condensation of alpha, alpha'-dibromo-p-xylene (I) with 4-hydroxyacetophenone (II) in the presence of K2CO3 affords 4-[(4-bromomethyl)benzyloxy]acetophenone (III). Subsequent condensation of bromide (III) with pyrrolidine, followed by conversion to the corresponding oxalate salt furnishes the title compound.

参考文献No.	723259
标题:	Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(Phenoxymethyl)benzyl)piperidines and related compounds
作者:	Mik? T.; Ligneau, X.; Pertz, H.H.; Ganellin, C.R.; Arrang, J.-M.; Schwartz, J.-C.; Schunack, W.; Stark, H.
来源:	J Med Chem 2003,46(8),1523

合成路线图解说明: Condensation of alpha, alpha'-dibromo-p-xylene (I) with 4-hydroxyacetophenone (II) in the presence of K2CO3 affords 4-[(4-bromomethyl)benzyloxy]acetophenone (III). Subsequent condensation of bromide (III) with pyrrolidine, followed by conversion to the corresponding oxalate salt furnishes the title compound.