(S)-4?(CH3O)-DADFT-药物合成数据库

【药物名称】(S)-4?(CH3O)-DADFT

化学结构式(Chemical Structure):

参考文献No.	723246
标题:	Methoxylation of desazadesferrithiocin analogues: Enhanced iron clearing efficiency
作者:	Bergeron, R.J.; Wiegand, J.; McManis, J.S.; Bussenius, J.; Smith, R.E.; Weimar, W.R.
来源:	J Med Chem 2003,46(8),1470

合成路线图解说明: Heating 2-hydroxy-4-methoxybenzaldehyde (I) with nitroethane and sodium acetate in AcOH furnishes 2-hydroxy-4-methoxybenzonitrile (II). This is then condensed with D-alpha-methylcysteine旽Cl (III) in the presence of pH 6 phosphate buffer to generate the target thiazoline.