【药物名称】NS-5845
化学结构式(Chemical Structure):
参考文献No.721737
标题:Bioisosteric modification of iGluR5 selective glutamate antagonists
作者:Valgeirsson, J.; Peters, D.; Madsen, U.; Nielsen, E.O.
来源:225th ACS Natl Meet (March 23 2003, New Orleans) 2003,Abst MEDI 197
合成路线图解说明:

2-Amino-4-chlorobenzonitrile (I) is reacted with NaN3 in the presence of NH4Cl to produce the tetrazole derivative (II). Further condensation of the aminophenyltetrazole (II) with 3-bromophenyl isocyanate (III) gives rise to the desired N,N'-diaryl urea.

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