-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	52220
标题:	New cpds. having anticancer activity: Process for their preparation and pharmaceutical compsns. containing them
作者:	Akella, V.; Nanduri, S.; Rajagopal, S. (Dr. Reddy's Research Foundation)
来源:	US 6576662; WO 0185709

合成路线图解说明: Conjugate addition of benzylamine to 3,14,19-triacetyl andrographolide (I) with concomitant elimination of the 14-acetoxy group leads to the butenolide derivative (II). The amino group of (II) is then acylated by chloroacetyl chloride in the presence of Et3N to produce the title chloroacetamide (1,2)

参考文献No.	721729
标题:	Synthesis and SAR studies of C-12 substituted andrographolide analogs as novel anticancer agents
作者:	Nanduri, S.; Thunuguntla, S.S.R.; Nyavanandi, V.K.; Akella, V.; Deevi, D.S.; Kasu, S.; Pallerla, M.K.; Rajagopal, S.; Ramanujam, R.; Reka, A.K.; et al.
来源:	225th ACS Natl Meet (March 23 2003, New Orleans) 2003,Abst MEDI 94

合成路线图解说明: Conjugate addition of benzylamine to 3,14,19-triacetyl andrographolide (I) with concomitant elimination of the 14-acetoxy group leads to the butenolide derivative (II). The amino group of (II) is then acylated by chloroacetyl chloride in the presence of Et3N to produce the title chloroacetamide (1,2)