【药物名称】
化学结构式(Chemical Structure):
参考文献No.721731
标题:SAHA derived inhibitors of histone deacetylase (HDAC)
作者:Belvedere, S.; Zhou, W.; Witter, D.; Yan, J.; Chen, W.; Secrist, J.P.; Richon, V.; Miller, T.
来源:225th ACS Natl Meet (March 23 2003, New Orleans) 2003,Abst MEDI 102
合成路线图解说明:

3-(Benzyloxy)aniline (I) is acylated by suberic acid mono-methyl ester (II) either employing EDC as the coupling reagent or via activation with oxalyl chloride to produce the suberoyl anilide (III). Further displacement of the methyl ester group of (III) with hydroxylamine in the presence of NaOMe leads to the target hydroxamic acid

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