-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	31705
标题:	Diaryl-5-oxygenated-2-(5H)-furanones as COX-2 inhibitors
作者:	Black, C.; Grimm, E.; Wang, Z.; Leger, S. (Merck Frosst Canada Inc.)
来源:	EP 0828724; JP 1999505534; US 5691374; WO 9636623

合成路线图解说明: Condensation between 4-methylsulfonyl-2'-bromopropiophenone (I) and 4-chlorophenylacetic acid (II) in the presence of Et3N/DBU, followed by air oxidation, gives rise to the furanone derivative (III) (1). This is subsequently hydrolyzed with ethanolic NaOH to produce the title keto carboxylate compound (1,2).

参考文献No.	725405
标题:	3,4-Diaryl-5-hydroxyfuranones: Highly selective inhibitors of cyclooxygenase-2 with aqueous solubility
作者:	Black, W.C.; Brideau, C.; Chan, C.-C.; Charleson, S.; Cromlish, W.; Gordon, R.; Grimm, E.L.; Hughes, G.; Leger, S.; Li, C.-S.; Riendau, D.; Therien, M.; Wang, Z.; Xu, L.-J.; Prasit, P.
来源:	Bioorg Med Chem Lett 2003,13(6),1195

合成路线图解说明: Condensation between 4-methylsulfonyl-2'-bromopropiophenone (I) and 4-chlorophenylacetic acid (II) in the presence of Et3N/DBU, followed by air oxidation, gives rise to the furanone derivative (III) (1). This is subsequently hydrolyzed with ethanolic NaOH to produce the title keto carboxylate compound (1,2).