-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	737841
标题:	Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues
作者:	Mai, H.D.T.; Gaslonde, T.; Michel, S.; Tillequin, F.; Koch, M.; Bongui, J.-B.; Elomri, A.; Seguin, E.; Pfeiffer, B.; Renard, P.; David-Cordonnier, M.-H.; Laine, W.; Bailly, C.; Kraus-Berthier, L.; Leonce, S.; Hickman, J.A.; Pierre, A.
来源:	J Med Chem 2003,46(14),3072

合成路线图解说明: Dihydroxylation of the benzo[b]pyrano[3,2-h]acridinone derivative (I) by means of N-methylmorpholine-N-oxide in the presence of OsO4 leads to the cis-diol (II), which upon esterification with 4-pentenoyl chloride in pyridine furnishes a mixture of diester (III) and the title mono-pentenoate ester, which can be separated employing flash chromatography.