TPFA, Thiovir-药物合成数据库

【药物名称】TPFA, Thiovir

化学结构式(Chemical Structure):

参考文献No.	63942
标题:	Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
作者:	McKenna, C.E.
来源:	US 5183812

合成路线图解说明: The reaction of phosphonoformic acid trimethyl ester (I) with Lawesson's reagent in refluxing acetonitrile gives the thiophosphonate (II), which is hydrolyzed with 10 N NaOH.

参考文献No.	63943
标题:	Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
作者:	McKenna, C.E.
来源:	US 5072032

合成路线图解说明: The reaction of phosphonoformic acid trimethyl ester (I) with Lawesson's reagent in refluxing acetonitrile gives the thiophosphonate (II), which is hydrolyzed with 10 N NaOH.