Carazolol, BM-51052-药物合成数据库

【药物名称】Carazolol, BM-51052

化学结构式(Chemical Structure):

参考文献No.	47813
标题:	Triyclic diphenylamines derivatives
作者:	Leinert, H.; et al. (Boehringer Ingelheim GmbH)
来源:	CH 598216; DE 2240599; FR 2196165; GB 1369580; JP 49056973

合成路线图解说明: By condensation of 4-hydroxycarbazole (I) with epichlorohydrin (II) by means of NaOH in aqueous dioxane at 40 C to yield 4-(2,3-epoxypropoxy)carbazole (III), followed by treatment with isopropylamine (IV) in refluxing ethanol

参考文献No.	800679
标题:	Carazolol
作者:	Weetman, D.F.; Casta馿r, J.
来源:	Drugs Fut 1977,2(11),715

合成路线图解说明: By condensation of 4-hydroxycarbazole (I) with epichlorohydrin (II) by means of NaOH in aqueous dioxane at 40 C to yield 4-(2,3-epoxypropoxy)carbazole (III), followed by treatment with isopropylamine (IV) in refluxing ethanol